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A new biginelli reaction procedure using potassium hydrogen sulfate as the promoter for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one

✍ Scribed by Shujiang Tu; Fang Fang; Songlei Zhu; Tuanjie Li; Xiaojing Zhang; Qiya Zhuang

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 130 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410216

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✦ Synopsis

Abstract

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4‐dihydropyrimidin‐2(1__H__)‐one derivatives. This synthesis was performed using potassium hydrogen sulfate as the promoter in ethylene glycol solution. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (85–95%) and short reaction time (0.5–2 h).

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