A new beta-2 microglobulin allele in mice defined by DNA sequencing

A specific antibody response to HCV E2 e

A specific antibody response to HCV E2 elicited in mice by intramuscular inoculation of plasmid DNA containing coding sequences for E2

✍ V Tedeschi; T Akatsuka; J W Shih; M Battegay; S M Feinstone 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

As the chimpanzee, the only reliable animal model for hepatitis C virus (HCV) infection, is impractical for early stage testing of HCV vaccine candidates, we have evaluated the immune response in mice to an experimental plasmid based HCV vaccine. We used this system because DNA vaccines can be rapid