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A new benzoangelicin with strong photobiological activity

✍ Scribed by Lourdes Santana; Eugenio Uriarte; Lisa Dalla Via; Ornella Gia

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
114 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis

AbstractÐBenzoangelicins 4±6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4±6 exhibited cutaneous phototoxicity.

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