✦ LIBER ✦

A new autoradiographic approach for imaging forebrain dopamine distribution

✍ Scribed by Dr G. Frederick Wooten; Malcolm K. Horne

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 713 KB
Volume: 12
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410120206

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Regional distribution of carbon 14 activity in the forebrain was studied autoradiographically following systemic administration of tracer doses of L‐[^14^C]‐dopa to rats pretreated with carbidopa. Five minutes after the injection, regional forebrain distribution of carbon 14 varied with regional cerebral blood flow. At 45 minutes, 2 hours, and 4 hours after administration of ^14^C‐dopa, however, carbon 14 activity had accumulated selectively in forebrain regions rich in dopamine (e.g., the striatum, olfactory tubercle, and nucleus accumbens). A unilateral lesion of the substantia nigra markedly attenuated the accumulation of carbon 14 in the ipsilateral striatum, while reserpine pretreatment reduced by about 50% the accumulation of carbon 14 in the striatum bilaterally. These results outline a new autoradiographic method for mapping forebrain dopamine systems and suggest an approach to imaging brain dopaminergic neurons in humans by positron emission tomography.

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