A new attempt to design erodible terpolymers using computer-optimization methodology

✍ Scribed by Kazumichi Imasaka; Kozo Takayama; Masaru Yoshida; Hideki Omichi; Tsuneji Nagai

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 305 KB
• Volume: 28
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(92)90071-9

✦ Synopsis

Abstraet--Terpolymers (1200 ~ A~ w ~ 13,000) of L-lactic acid (LA), oL-mandelic acid (MA) and p-hydroxyphenylpropionic acid (HPPA) are subject to erosion which can be controlled by changing the composition of the polymer. On this basis, the computer optimization technique was tested for the design of an erodible terpolymer. Extreme vertices statistical design was applied to the synthesis of the controlled bio-erosion polymer. The composition ranges used in this study were 0.4~LA~ l, 0~MA~0.6 and 0 ~ HPPA ~ 0.6, respectively. The weight loss parameter of the terpolymer after a desired time was selected as primary response variable. These variables were predicted quantitatively by multiple regression equations. The experimental results agree well with the predictions, indicating that the computer optimization technique is applicable to control the degree of erosion of poly(LA/MA/HPPA) as a function of composition.