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A new asymmetric route to synthetically useful γ-substituted γ-butyrolactones

✍ Scribed by Jarosław Kiegiel; Jacek Nowacki; Aldona Tarnowska; Małgorzata Stachurska; Janusz Jurczak

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
100 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The results of asymmetric hydrogenation of diethyl 3,4-dioxohexanedioate are presented. (R,R)-1,5-Dioxa-2,6-dioxobicyclo[3.3.0]octane, the product of hydrogenation and subsequent cyclization, was obtained in high enantiomeric excess. This compound was transformed into synthetically useful (R)-4-hydroxyethyl-2-buten-4olide.

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