A new association test based on disease allele selection for case–control genome-wide association studies
✍ Scribed by Chen, Zhongxue
- Book ID
- 125397349
- Publisher
- BioMed Central
- Year
- 2014
- Tongue
- English
- Weight
- 238 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1471-2164
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## Abstract Genetic association is often determined in case‐control studies by the differential distribution of alleles or genotypes. Recent work has demonstrated that association can also be assessed by deviations from the expected distributions of alleles or genotypes. Specifically, multiple meth
In case-control genetic association studies, the robust procedure, Pearson's Chi-square test, is commonly used for testing association between disease status and genetic markers. However, this test does not take the possible trend of relative risks, which are due to genotype, into account. On the co