A New Arrangement for the Anticancer Antibiotics Tallysomycin and Bleomycin When Bound to Zinc: An Assessment of Metal and Ligand Chirality by NMR and Molecular Dynamics

ChemInform Abstract: A New Arrangement f

ChemInform Abstract: A New Arrangement for the Anticancer Antibiotics Tallysomycin and Bleomycin When Bound to Zinc: An Assessment of Metal and Ligand Chirality by NMR and Molecular Dynamics.

✍ A. M. CALAFAT; H. WON; L. G. MARZILLI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB

The structure of the Zn complex of tallysomycin A, which is closely related to the bleomycin glycopeptide antibiotic, is determined by NMR spectra including calculations of restrained molecular mechanics and molecular dynamics and the comparison of experimental and simulated spectra. -(CALAFAT, A.