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A new approach toward a pancreas-seeking zinc radiopharmaceutical

✍ Scribed by Yasuhisa Fuijbayashi; Hideo Saji; Isamu Yomoda; Kazuko Horiuchi Suzuki; Kanji Torizuka; Akira Yokoyama

Publisher
Springer
Year
1986
Tongue
English
Weight
707 KB
Volume
11
Category
Article
ISSN
0340-6997

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✦ Synopsis

The functionality of various zinc complexes of amino acid derivatives as a zinc radiopharmaceutical for pancreas PCT imaging was tested using 65Zn, which has a long half-life, and 62Zn, which has a short half-life. Because of the favorable results obtained in previous in vitro pancreas section studies, the ability of those Zn complexes to retain their integrity in the presence of blood serum or in living organisms was screened using Sephadex column chromatography and mice biodistribution studies. A relationship between the structure and stability of Zn complexes played a determining role on the in vivo availability of Zn for the pancreas or liver. Among the Zn complexes tested, the tetra-coordinated structure of the Zn-EDDA complex at an equimolar ratio showed proper accumulation in the pancreas, inducing an appropriate pancreas PCT image in the dog with the positron emitter 62Zn-EDDA administered at 1 mg Zn/kg body weight.

πŸ“œ SIMILAR VOLUMES

A new approach toward a pancreas-seeking
A new approach toward a pancreas-seeking zinc radiopharmaceutical
✍ Yasuhisa Fujibayashi; Hideo Saji; Isamu Yomoda; Kazuko Horiuchi Suzuki; Kanji To πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 457 KB

There have been many attempts to develop zinc-containing radiopharmaceuticals for use as pancreas-seeking agents, but little consideration has been given to Zn-complex structure as being a factor that contributes to Zn utilization by the pancreas. In the present study, various ligands having N-O don