A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines

✍ Scribed by Juan A. Vega; Juan J. Vaquero; Julio Alvarez-Builla; Jesús Ezquerra; Chafiq Hamdouchi

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 529 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00012-5

✦ Synopsis

A microwave (focused waves) assisted N-alkylation of 2-halopyridines provides a convenient entry to 2amino-imidazo[ 1,2-a]pyridine derivatives after reaction of the alkylated substrates with cyanamide under basic conditions.