## Abstract The commonly used methods for bioconversion kinetic parameter identification are linear plotting and nonlinear regression. However, linear plotting methods generally require considerable experimentation, and nonlinear regression can lead to βlocal optimizationβ because the obtained para
A new approach to the study of parameter insensitivity
β Scribed by C. Gori-Giorgi; O.M. Grasselli
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 542 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0005-1098
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β¦ Synopsis
The sensitivity properties of a linear system affected by parameter variations can be studied by means Of properly defined linear subspaces of the state space.
Summary--In this paper a new approach to the study of parameter insensitivity of a linear, time-varying, continuous and finite-dimensional system is introduced. Following this approach, a unique theory is developed for the analysis of insensitivity to both 'large' and 'small' parameter variations; moreover, a decomposition of the system into four subsystems is obtained which is based on the dependence upon parameters of both the inputstate and state-output relationships.
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## Abstract A linear threeβcompartment model is proposed as a means of estimating disposition and extracorporeal elimination pharmacokinetic parameters during haemodialysis. It was created by connecting a compartment, corresponding to the amount of drug present in the dialysis cell, to the central