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A new approach to the 2,5-diamino-5,6-dihydro-1H-pyrimidine-4-one derivatives: synthesis of TAN-1057A/B and analogs

✍ Scribed by Lijun Zhang; Lianhong Xu; Choung U. Kim


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
254 KB
Volume
44
Category
Article
ISSN
0040-4039

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Cascade assembly of N,Nβ€²-dialkylbarbitur
✍ Michail N. Elinson; Anatolii N. Vereshchagin; Nikita O. Stepanov; Pavel A. Belya πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 249 KB

Cascade assembly of N,N 0 -dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2H,2 0 H-spiro(furo[2,3-d]pyrimidine-6,5 0pyrimidine)-2,2 0 ,4,4 0 ,6 0 -(1 0 H,3H,3 0 H)-pentones in 70-88% yields via a complex casc