## Abstract A synthesis of nicotyrine (**9**), and hence formally racemic nicotine, was carried out by elaboration of the 1β:β1 adduct **2** of cyclooctaβ1,5βdiene and chlorosulfonyl isocyanate (ClSO~2~ο£ΏNCO). Transformation of adduct **2** into carbamate **4** was followed by ozonolysis, tosylation
A New Approach to Nicotine: Symmetry Consideration for Synthesis Design.
β Scribed by Tse-Lok Ho; Eugene V. Kuzakov
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image A straightforward and practical approach was established for the synthesis of nicotine and anabasine analogues by the cyclization of mesylated 1β(3βpyridinyl)β1,4, and 1,5βdiol derivatives to form the pyrrolidino or piperidino fragments. Nicotine analogue (__S__)β**15**
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