A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of Nα-Fmoc-Nα-(Hmb)amino acids
✍ Scribed by Ernesto Nicolás; Montse Pujades; Jordi Bacardit; Ernest Giralt; Fernando Albericio
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 371 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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4-Phosphoranylidene-5(4H)-oxazolones 1 undergo hydrolysis in THF in the presence of HBF 4 at room temperature to give N-acyl-atriphenylphosphonioglycines 3 (R 2 = H) in very good yields. 4-Alkyl-4-triphenylphosphonio-5(4H)-oxazolones 2 react with water in CH 2 Cl 2 /THF solution without any acidic c
## Abstract The growing interest in the 1,4‐disubstituted‐1,2,3‐triazolyl moiety as an amide bond surrogate and its formation through very mild, chemoselective, and bioorthogonal Cu^I^‐catalyzed Huisgen 1,3‐dipolar [3+2] cycloaddition of an alkynyl to an azido function, presented an unmet need for