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A new approach to 4-(2-aminoethyl)indoles via Claisen ortho-amide rearrangement of 3-hydroxy-2-methoxyindolines

✍ Scribed by Kawasaki, Tomomi; Ohtsuka, Hiroaki; Sakamoto, Masanori


Book ID
111871339
Publisher
The Royal Society of Chemistry
Year
1990
Tongue
English
Weight
150 KB
Volume
10
Category
Article
ISSN
0022-4936

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Claisen rearrangement of Ξ³-hydroxyvinyl
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In situ prepared ketene acetals of 7-hydroxyvinyl sulfones undergo a Claisen rearrangement affording 3-phenylsulfonyl esters.These compounds are converted to (2E,4E)-dienoic esters by a base-assisted elimination of benzenesulfinic acid.