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A new approach for the determination of the absolute configuration of secondary alcohols by 1H NMR with O-substituted mandelate derivatives

✍ Scribed by Isabelle Chataigner; Jacques Lebreton; Didier Durand; André Guingant; Jean Villiéras

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 223 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00059-8

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✦ Synopsis

It is shown that the cheap and easily prepared mandelic acid esters (or their OAc analogues) are best suited than the expensive, although usually employed, OMe mandelic acid esters to assess both the enantiomeric excesses and absolute configurations of secondary alcohols.

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