A new annulation reaction using the stereoselective activation of “benzylic” protons in the Cr(CO)3 complexes of indanone and tetralone derivatives. Gérard Jaouen
✍ Scribed by André Meyer
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 229 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
In the syntheses of natural products the methods of formation of 5 and 6-membered additional rings from a pre existing cyclic ketone have undoubtedly attracted a great deal of attention. Problems concerned inter atia with the processes of annulation and the stereochemistry of molecules derived from the "indanone" and "tetralone" skeletons have been discussed extensively (I, 2). The modification of synzaetry on incorporation of the Cr(C0)3 moiety allowed access to optically active I-indanone and I-tetralone Cr(C0)3 (3). Moreover, the ease of complexation and displacement of the Cr(C0)3 activating group makes it a reagent of choice in synthesis. Further applications of this principle with respect to the chemistry of natural products seemed promising.
We report here our preliminary results in this specific area.