✦ LIBER ✦
A New and Simply Available Class of Hydrosoluble Bioconjugates by Coupling Paclitaxel to Hyaluronic Acid through a 4-Hydroxybutanoic Acid Derived Linker
✍ Scribed by Francesca Leonelli; Angela La Bella; Andrea Francescangeli; Roberta Joudioux; Agostina-Lina Capodilupo; Marina Quagliariello; Luisa M. Migneco; Rinaldo Marini Bettolo; Vittorio Crescenzi; Gilda De Luca; Davide Renier
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- German
- Weight
- 84 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4‐hydroxybutanoic acid derived linker (Scheme 2).