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A New and Highly Efficient Asymmetric Route to Cyclic α-Amino Phosphonates: The First Catalytic Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes

✍ Scribed by Gröger, Harald; Saida, Yoshinobu; Sasai, Hiroaki; Yamaguchi, Kentaro; Martens, Jürgen; Shibasaki, Masakatsu


Book ID
127364643
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
327 KB
Volume
120
Category
Article
ISSN
0002-7863

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First catalytic asymmetric hydrophosphon
✍ Harald Gröger; Yoshinobu Saida; Shigeru Arai; Jürgen Martens; Hiroaki Sasai; Mas 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 160 KB

The catalytic and enantioseleetive hydrophosphonylation of a cyclic imine, namely the 3thiazoline I, is described. We have discovered a highly efficient enantioselective de novo approach to the pharmaceutically interesting 4-thiazolidinylphosphonate 2 using either titanium or lanthanoid chiral catal