A new and facile synthesis of methyl 3-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxylate
✍ Scribed by Lukáš Tenora; Marian Buchlovič; Stanislav Man; Milan Potáček
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 307 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 2‐Amino‐3‐cyano‐4,5,6,7‐tetrahydrobenzo[__b__]thiophene **1a** or 2‐amino‐3‐cyano‐4,7‐di‐ phenyl‐5‐methyl‐4__H__‐pyrano[2,3‐__c__]pyrazole **2a** reacted with phenylisocyanate in dry pyridine to give 2‐(3‐phenylureido)‐3‐cyanobenzo[b]thiophene **1b** or 2‐disubstituted amino‐3‐cyanopyra
## Abstract This paper describes the synthesis of some 5‐amino‐1,2,3,4‐tetrahydrobenzo[__b__][1,7]naphthyridines and 2,3,4,4a,5,6‐hexahydrobenzo[__c__][2,6] naphthyridines starting from anilines and 1‐benzyl‐4‐ethoxycarbonylpiperidin‐3‐one. The compounds were prepared in order to study their potent