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A new and facile synthesis of imidazo[2,1-b]oxazoles

✍ Scribed by Belew Mekonnen; George Crank; Donald Craig


Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
967 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

An efficient and clean two step procedure for the synthesis of imidazo[2,1‐b]oxazoles has been developed from 2‐aminooxazoles using titanium(IV) chloride assisted cyclization, and a variety of imidazo[2,1‐b]oxazoles have been synthesized in good yields. The structure of one of the products was confirmed by X‐ray crystallographic analysis.


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## Abstract 5‐Oxo‐5__H__‐[1,3]thiazolo[3,2‐__a__]pyrimidine‐6‐carboxylic acid (**4**), and 6‐methylimidazo[2,1‐__b__]thiazole‐5‐carboxylic acid (**17**) were reacted with amines **6a‐i** by the reaction with oxalyl chloride and __N, N__‐di methyl‐formamide as a catalyst into primary and secondary a