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A new and efficient synthesis of trifluoromethyl ketones from carboxylic acids. Part I

✍ Scribed by Jean Boivin; Laurent El Kaim; Samir Z Zard


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
729 KB
Volume
51
Category
Article
ISSN
0040-4020

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Direct Preparation of Trifluoromethyl Ke
✍ JΓΌrgen Wiedemann; Thomas Heiner; Gregorz Mloston; G. K. Surya Prakash; George A. πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 72 KB πŸ‘ 1 views

Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane