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A new and efficient synthesis of (−)-indolizidine 167B by tandem metathesis

✍ Scribed by Jan Zaminer; Christian Stapper; Siegfried Blechert


Book ID
104251859
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
74 KB
Volume
43
Category
Article
ISSN
0040-4039

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Asymmetric Heck cyclization route to ind
✍ Kurt Kiewel; Mathew Tallant; Gary A Sulikowski 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 85 KB

Asymmetric intramolecular Heck cyclization of endocyclic enamides occurs at room temperature to give indoloizidine and azaazulene ring systems in up to 86% enantiomeric excess. A synthesis of (+)-epiindolizidine 167B and formal synthesis of 5E,9Z-indolizidine 223AB is described.