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A new and efficient route toward the preparation of diazo ketones using cyanuric chloride and diazomethane

✍ Scribed by David C Forbes; Elvis J Barrett; Derrick L Lewis; Mary C Smith

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
69 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new method for the preparation of diazo ketones has been developed. 2,4,6-Trichloro-1,3,5-triazine (cyanuric chloride) has been found to be an excellent coupling reagent allowing for the efficient transfer of diazomethane to a carboxylic acid. Preparation of diazo ketones using carboxylic acids and triazine reagents is considerably more convenient than classical diazo transfer protocols because water does not have to be stringently removed and the entire procedure can be carried out in one-pot. Electron deficient and neutral aryl carboxylic acids were found to give better results than electron rich or aliphatic carboxylic acids.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: A New and Efficient
ChemInform Abstract: A New and Efficient Route Toward the Preparation of Diazo Ketones Using Cyanuric Chloride and Diazomethane.
✍ David C. Forbes; Elvis J. Barrett; Derrick L. Lewis; Mary C. Smith πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons βš– 30 KB

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