A new and efficient method for the resolution of 1,1'-binaphthalene-2,2'-diol
β Scribed by Brunel, Jean Michel; Buono, Gerard
- Book ID
- 118742231
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 228 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The synthesis and resolution of 3,3%-bis(benzyloxy)-1,1%-binaphthalene-2,2%-diol 1 is described. A diastereomeric mixture of 7 (derived from (Β±)-1 and Boc-Ala-OH) was separated using crystallization and column chromatography.
## Abstract An economic and practical method for preparing enantiomerically pure [1,1β²βbinaphthalene]β2,2β²βdiols is reported. Thus, a condensate of __threo__β(1__S__,2__S__)β2βaminoβ1β(4βnitrophenyl)propaneβ1,3βdiol and cyclohexanone (CHANP) was used as a resolving agent. A 2β:β1β:β1 mixture of rac