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A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases

✍ Scribed by Aung, Gyi; Niyonsaba, François; Ushio, Hiroko; Hoq, Md. Imranul; Ikeda, Shigaku; Ogawa, Hideoki; Okumura, Ko

Book ID: 119293689
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 251 KB
Volume: 61
Category: Article
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2010.11.006

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi