A neurite outgrowth-inhibitory proteoglycan expressed during development is similar to that isolated from adult brain after isomorphic injury
✍ Scribed by Fernaud-Espinosa, Isabel ;Nieto-Sampedro, Manuel ;Bovolenta, Paola
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 551 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
The expression of proteoglycans ated against IMP. The comparison of PMP and IMP (PGs) in the mammalian central nervous system properties indicates that the two PGs are highly re-(CNS) appears to be strictly regulated both during lated and share expression patterns, biochemical chardevelopment and after damage to the mammalian acteristics, and the ability to inhibit neurite initiation CNS. Recently, we have isolated from membranes of in culture. However, IMP and PMP displayed a disinjured adult brain a neurite outgrowth-inhibitory tinct effect on neurite elongation, which may be exproteoglycan (IMP), the activity of which could be plained by their differences in glycosilation pattern. specifically counteracted by a monoclonal antibody
The data presented in this report support the idea that (mAB) against the PG. We described in this report the proteoglycans expressed during CNS development are characterization of perinatal membrane proteoglycan re-expressed following injury. ᭧ 1998 John Wiley & Sons, (PMP), a heparan-sulfate/chondroitin-sulfate-con-