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A national DNA bank in The Gambia, West Africa, and genomic research in developing countries

✍ Scribed by Sirugo, Giorgio; Loeff, Maarten Schim Van Der; Sam, Omar; Nyan, Ousman; Pinder, Margaret; Hill, Adrian V; Kwiatkowski, Dominic; Prentice, Andrew; de Toma, Claudia; Cann, Howard M.


Book ID
109916555
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
99 KB
Volume
36
Category
Article
ISSN
1061-4036

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Ser-249TP53 mutation in tumour and plasm
✍ Katarzyna SzymaΕ„ska; Olufunmilayo A. Lesi; Gregory D. Kirk; Omar Sam; Philippe T πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 240 KB

## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGGβ†’AGT at codon 249, Argβ†’Ser) has been identified as a hotspot in HCCs from such areas,