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A Mystery Wrapped in an Enigma: Matrigel Enhancement of Mammary Cell Growth and Morphogenesis

✍ Scribed by Michael T. Lewis, John D. Landua, Homer C. Adams III, Daniel Medina


Book ID
118803004
Publisher
Springer US
Year
2012
Tongue
English
Weight
81 KB
Volume
17
Category
Article
ISSN
1083-3021

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IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect