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A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket

✍ Scribed by Robert Maurus; Christopher M Overall; Ralf Bogumil; Yaoguang Luo; A.Grant Mauk; Michael Smith; Gary D Brayer


Book ID
114149454
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
370 KB
Volume
1341
Category
Article
ISSN
0167-4838

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We investigated the inhibitory activity of several 1,3,4-thiadiazole-sulfonamides against all catalytically active CA (EC 4.2.1.1), CA I-XV. The tail derivatizing the 5-position in the 1,3,4-thiadiazole-2-sulfonamide scaffold was observed to be critical as an inhibitory determinant of these compound