A myeloproliferative disorder may hide another one

✍ Scribed by Sophy Laibe; Zoulika Tadrist; Christine Arnoulet; Danielle Sainty; Marie-Joëlle Mozziconacci

• Book ID: 104040979
• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 307 KB
• Volume: 33
• Category: Article
• ISSN: 0145-2126
• DOI: 10.1016/j.leukres.2009.01.034

✦ Synopsis

Chronic myeloproliferative disorders (MPDs) are divided into Philadelphia-positive chronic myeloid leukemia (CML) and Philadelphia-negative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis (IMF). Concomitance of a CML and another MPD is a rare event. We report here the case of a patient presenting initially with IMF who developed a Philadelphia-positive CML 7 years later. At the time of CML diagnosis, two distinct clones were present, one with a 13q deletion and one with a t(9;22). We raise the problem of a CML developing on an initial IMF, or two MPDs occurring from a common or two different stem cells.