Dissection of the DNA Mimicry of the Bac
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Augoustinos S. Stephanou; Gareth A. Roberts; Laurie P. Cooper; David J. Clarke;
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Article
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2009
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Elsevier Science
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English
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The homodimeric Ocr (overcome classical restriction) protein of bacteriophage T7 is a molecular mimic of double-stranded DNA and a highly effective competitive inhibitor of the bacterial type I restriction/modification system. The surface of Ocr is replete with acidic residues that mimic the phospha