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A Mutation in the Rett Syndrome Gene, MECP2, Causes X-Linked Mental Retardation and Progressive Spasticity in Males

✍ Scribed by Ilaria Meloni; Mirella Bruttini; Ilaria Longo; Francesca Mari; Flavio Rizzolio; Patrizia D'Adamo; Koenraad Denvriendt; Jean-Pierre Fryns; Daniela Toniolo; Alessandra Renieri


Book ID
117853426
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
129 KB
Volume
67
Category
Article
ISSN
0002-9297

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## Abstract Non‐syndromic X‐linked mental retardation (MRX) is a frequent cause of inherited mental retardation. It is a heterogeneous condition in which the first 12 genes discovered to date explain no more than 15% of the MRX situations ascertained by recurrence in multiplex families. In Rett syn