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A mutation in the largest (catalytic) subunit of RNA polymerase II and its relation to the arrest of the cell cycle in G1 phase

✍ Scribed by Kimihiko Sugaya; Shun-ichi Sasanuma; Peter R. Cook; Kazuei Mita

Book ID: 117520477
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 251 KB
Volume: 274
Category: Article
ISSN: 0378-1119
DOI: 10.1016/s0378-1119(01)00615-1

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio