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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

✍ Scribed by Jonsson, Thorlakur; Atwal, Jasvinder K.; Steinberg, Stacy; Snaedal, Jon; Jonsson, Palmi V.; Bjornsson, Sigurbjorn; Stefansson, Hreinn; Sulem, Patrick; Gudbjartsson, Daniel; Maloney, Janice; Hoyte, Kwame; Gustafson, Amy; Liu, Yichin; Lu, Yanmei; Bhangale, Tushar; Graham, Robert R.; Huttenlocher, Johanna; Bjornsdottir, Gyda; Andreassen, Ole A.; Jönsson, Erik G.; Palotie, Aarno; Behrens, Timothy W.; Magnusson, Olafur T.; Kong, Augustine; Thorsteinsdottir, Unnur; Watts, Ryan J.; Stefansson, Kari


Book ID
111963605
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
225 KB
Volume
488
Category
Article
ISSN
0028-0836

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## Objective: To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in alzheimer's disease (ad). ## Methods: A total of 472 persons with clinically diagnosed ad were recruited from a memory disorders clinic and day