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A Murine Monoclonal Antibody that Recognizes an Extracellular Domain of the Human c-erbB-2 Protooncogene Product

✍ Scribed by Masuko, Takashi ;Sugahara, Kunio ;Kozono, Mitsuko ;Otsuki, Seiko ;Akiyama, Tetsu ;Yamamoto, Tadashi ;Toyoshima, Kumao ;Hashimoto, Yoshiyuki


Book ID
108578881
Publisher
Wiley (Blackwell Publishing)
Year
1989
Tongue
English
Weight
257 KB
Volume
80
Category
Article
ISSN
0910-5050

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## Abstract Over‐expression of the c‐__erb__B‐2 (HER‐2/__neu__) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells