✦ LIBER ✦

A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits

✍ Scribed by George P. Vogler; Weihong Tang; Tracy L. Nelson; Scott M. Hofer; Julia D. Grant; Lisa M. Tarantino; Jose R. Fernandez

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 112 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<921::aid-gepi60>3.0.co;2-n

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✦ Synopsis

A model was developed to detect effects of quantitative trait loci (QTLs) in sibships from simulated nuclear family data using the full covariance structure of the data and analyzing all five quantitative traits simultaneously in a multivariate model. Evidence of the presence of loci was detected on chromosomes 4, 8, 9, and 10. The method provided stable results and is worth further exploration for its performance and optimal sample size requirements under realistic conditions.