A multivalent recombinant antibody fragment specific for carcinoembryonic antigen
✍ Scribed by Lincidio Perez; Marta Ayala; Gilmara Pimentel; Hanssel Bell; Leonardo Canaán-Haden; Mónica Bequet; Luis Javier González; Marlen Miranda; Rolando Ravelo; Lourdes Roque; Boris Acevedo; Juan P. Oliva; Jorge V. Gavilondo
- Book ID
- 111718080
- Publisher
- Portland Press
- Year
- 2006
- Tongue
- English
- Weight
- 438 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0885-4513
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## Abstract Production of recombinant antibody fragments in bacterial expression systems results in intentional or fortuitous differences compared to the original products prepared by hybridoma technology. These differences may have significant effects not only on antigen‐binding properties but als
## Abstract Rabbit or goat antibodies to a human colonic cancer cell line (HT‐29) and to carcinoembryonic antigen (CEA) were studied with respect to their ability to cause complement‐mediated and enzyme‐mediated cytotoxicity. IgG fractions of normal sera and antisera to CEA and HT‐29 were prepared