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A Multipoint Method for Detecting Genotyping Errors and Mutations in Sibling-Pair Linkage Data

โœ Scribed by Julie A. Douglas; Michael Boehnke; Kenneth Lange


Book ID
117853240
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
651 KB
Volume
66
Category
Article
ISSN
0002-9297

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The detection of genotyping errors, based on apparent Mendelian incompatibilities in a sample of sib-pairs, is a complicated problem. In the case of a single marker and unknown parental genotypes, all combinations of sib-pair genotypes are self-consistent. Moreover, the observed deviation from equil