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A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice

✍ Scribed by Daria Cipollone; Francesca Amati; Rita Carsetti; Silvia Placidi; Michela Biancolella; Giulia D'Amati; Giuseppe Novelli; Gregorio Siracusa; Bruno Marino

Book ID: 116342561
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 525 KB
Volume: 15
Category: Article
ISSN: 1054-8807
DOI: 10.1016/j.carpath.2006.04.004

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We previously reported that retinoic acid shows a dose-dependent differential induction of various cardiac outflow anomalies: transposition of the great arteries is induced mainly by a high dose (70 mg/kg) and dextroposition of the aorta by a low dose (40-60 mg/kg; Yasui et al., 1995). We subsequent

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## Background: In the mouse model of complete transposition of the great arteries (tga) produced by all-trans retinoic acid (ra), parietal and septal ridges in the outflow tract (ot) are hypoplastic. at first, these ridges are generated by an expanded cardiac jelly (mainly myocardial basement membr

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## Background: The major morphologic change associated with retinoic acid (RAbinduced complete transposition of the great arteries (TGA), a congenital malformation of the heart, was investigated in a mouse model in which TGA was found in 80% of surviving fetuses. Methods: Corrosion casts of embryo