✦ LIBER ✦

A multiple chemotherapeutic approach to the management of hepatoblastoma. A preliminary report

✍ Scribed by Ciiarlene P. Holton; John D. Burrington; Edwin I. Hatch

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 370 KB
Volume: 35
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197504)35:4<1083::aid-cncr2820350410>3.0.co;2-k

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✦ Synopsis

In 1970, a staging based on surgical resectability of hepatic tumors was devised. Adjuvant chemotherapy with vincristine, 5-fluorouracil, and cyclophosphamide has been given to seven recent cases. Objectives of this study were to set up unified clinical staging and followup; to evaluate the effect of combination chemotherapy on survival in advanced disease; and to evaluate early adjunctive combination chemotherapy in surgically resectable lesions to, hopefully, prevent metastasis. Results to date in seven patients are: no change in the poor prognosis of the three female patients presenting with Stage III-IV hepatocellular carcinoma; the three males with Stage I-II hepatoblastoma have done well and survive the free of disease at 47 months, 44 months, and 28 months; one patient with hepatoblastoma had lung metastasis at diagnosis and died at 7 months with tumor. No toxicity was noted with the use of adjunctive combination chemotherapy following major hepatic resection.

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