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A multiparametric index of platelet in vitro aggregation in cerebrovascular disease

✍ Scribed by P. P. Gazzaniga; P. Ferroni; C. Mina; F. M. Pulcinelli; P. A. Rizzo

Publisher
Springer Milan
Year
1987
Tongue
English
Weight
467 KB
Volume
8
Category
Article
ISSN
1590-1874

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The mycotoxin ochratoxin A (OA) consists of 5-chloro-3-methyl-3,4-dihydro-8-hydroxyisocoumarin moiety linked by an amide bond to p-Lphenylalanine. When added to washed rat platelets in vitro, OA caused a dose-dependent inhibition of aggregation induced by agonists such as adenosine diphosphate (ADP)