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A multinuclear magnetic resonance study of protonation in imidazo[1,2-a]pyrazine

✍ Scribed by P. N. Sanderson; R. D. Farrant; J. C. Lindon; P. Barraclough

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
337 KB
Volume
28
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

^1^H and ^13^C NMR spectra are reported and assigned for imidazo[1,2‐a] pyrazine and for N‐1‐methyl‐ and N‐7‐methyl‐imidazo[1,2‐a] pyrazinium iodides. The effect of protonation on the chemical shifts of the parent molecule is demonstrated, and through the use of ^13^C and ^15^N NMR spectra the site of protonation is deduced to be at N‐1, in contrast to 2‐aryl substituted compounds synthesised as potential cardiotonic agents where protonation occurs at N‐7.

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