A multilevel model framework for meta-analysis of clinical trials with binary outcomes
β Scribed by Rebecca M. Turner; Rumana Z. Omar; Min Yang; Harvey Goldstein; Simon G. Thompson
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 112 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The aim of this contribution is to give an overview of approaches to testing for nonβinferiority of one out of two binomial distributions as compared to the other in settings involving independent samples (the paired samples case is not considered here but the major conclusions and reco
Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert
We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designsthe randomized play-the-winner rule and the triangular test. The
## Abstract ## Background This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins. ## Methods Some 280 patients were randomized equally using sealed opaque envelopes to two parallel groups: s