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A multicenter, double-blind, placebo-controlled phase IIb proof-of-concept dose-ranging study of AZD3480 and donepezil over 12 weeks in patients with mild to moderate Alzheimer's disease

✍ Scribed by Lutz Frölich; Göran Eckerwall; Nilsson Jonas


Book ID
118465271
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
45 KB
Volume
5
Category
Article
ISSN
1552-5260

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Background. Metrifonate is a long-lasting acetylcholinesterase inhibitor being developed for the symptomatic treatment of Alzheimer's disease (AD). Objectives. This study compared the ecacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate AD, over a 26-week tre