A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention
β Scribed by Nicola Zanesi; Yuri Pekarsky; Carlo M. Croce
- Book ID
- 113808708
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 196 KB
- Volume
- 591
- Category
- Article
- ISSN
- 0027-5107
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Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s
## Abstract ## Background Geneβdirected enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar