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A mouse model for the learning and memory deficits associated with neurofibromatosis type I

✍ Scribed by Silva, Alcino J.; Frankland, Paul W.; Marowitz, Zachary; Friedman, Eugenia; Lazlo, George; Cioffi, Dianna; Jacks, Tyler; Bourtchuladze1 4, Roussoudan

Book ID: 109915468
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 459 KB
Volume: 15
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng0397-281

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## Abstract The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production of inactive rasGDP, with wide‐ranging effects on p21ras pathw