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A more selective costimulatory blockade of the CD28-B7 pathway

✍ Scribed by Nicolas Poirier; Gilles Blancho; Bernard Vanhove

Book ID
110917509
Publisher
Springer
Year
2010
Tongue
English
Weight
224 KB
Volume
24
Category
Article
ISSN
0934-0874

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## Abstract While the importance of the CD28/B7 costimulation pathway is well established for mature T cells, the role of CD28 in thymocyte selection is less well defined. The role of CD28 in both negative and positive selection was assessed using H‐Y‐specific TCR‐transgenic (Tg) RAG‐2‐deficient (H