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A monoclonal antibody recognising the site of limited proteolysis of protein kinase C : Inhibition of down-regulation in vivo

✍ Scribed by Susan YOUNG; Johnathan ROTHBARD; Peter J. PARKER


Book ID
115125713
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
977 KB
Volume
173
Category
Article
ISSN
1432-1327

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo