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A monoclonal antibody, anti-Tac, blocks the action and membrane binding of human interleukin-2 (IL-2)

โœ Scribed by J.M. Depper; W.J. Leonard; T. Uchiyama; K.A. Smith; T.A. Waldmann; W.C. Greene

Book ID
113132347
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
102 KB
Volume
70
Category
Article
ISSN
0008-8749

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Blocking of interleukin 2 (IL 2) binding
Blocking of interleukin 2 (IL 2) binding to the IL 2 receptor is not required for the in vivo action of anti-IL 2 receptor monoclonal antibody (mAb). I. The production, characterization and in vivo properties of a new mouse anti-rat IL 2 receptor mAb that reacts with an epitope different to the one that binds to IL 2 and the mAb ART-18
โœ Athanasia Mouzaki; Hans-Dieter Volk; Hisao Osawa; Tibor Diamantstein ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 727 KB

A mouse anti-rat interleukin 2 (IL 2) receptor (IL 2R) monoclonal antibody (mAb), ART-65, has been developed. As shown by fluorescence-activated cell sorter analysis and immunoprecipitation studies, ART-65 recognizes in a species-specific manner the same molecule as does ART-18, a mAb which has been